RS 504393，CCR2 chemokine receptor拮抗剂(ab120813)
Key features and details
- Highly selective CCR2 chemokine receptor antagonist
- CAS Number: 300816-15-3
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
RS 504393，CCR2 chemokine receptor拮抗剂 -
描述
Highly selective CCR2 chemokine receptor拮抗剂 -
生物学描述
Highly selective CCR2 chemokine receptor antagonist (IC50 = 89 nM). Shows 700-fold greater binding for CCR2 vs. CCR1. Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
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纯度
> 98% -
CAS编号
300816-15-3 -
化学结构
性能
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化学名称
6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one -
分子量
417.51 -
分子式
C25H27N3O3 -
PubChem识别号
9953769 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C -
来源
Synthetic
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研究领域
图片
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Chemical Structure - RS 504393, CCR2 chemokine receptor antagonist (ab120813)2D chemical structure image of ab120813, RS 504393, CCR2 chemokine receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab120813 尚未被引用在任何文献中。