Rosiglitazone，PPARgamma激动剂(ab120762)
Key features and details
- Selective PPARγ agonist
- CAS Number: 122320-73-4
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM (with warming)
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Rosiglitazone，PPARgamma激动剂 -
描述
Selective PPARγ激动剂 -
生物学描述
Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.
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纯度
> 99% -
CAS编号
122320-73-4 -
化学结构
性能
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化学名称
5-[[4- [2- (Methyl- 2- pyridinylamino) ethoxy] phenyl] methyl] - 2,4- thiazolidinedione -
分子量
357.43 -
分子式
C18H19N3O3S -
PubChem识别号
77999 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 100 mM (with warming) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3 -
来源
Synthetic
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研究领域
相关产品
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120762于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Rosiglitazone, PPARgamma agonist (ab120762)2D chemical structure image of ab120762, Rosiglitazone, PPARgamma agonist
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Immunocytochemistry/ Immunofluorescence - Rosiglitazone, PPARgamma agonist (ab120762)ab3580 staining glucocorticoid receptor in serum starved HeLa cells treated with rosiglitazone (120762), by ICC/IF. Changes in localization of glucocorticoid receptor (translocation from cytoplasm to nucleous) correlates with increased concentration of rosiglitazone, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120762 (rosiglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab3580 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (8)
ab120762 被引用在 8 文献中.
- Antoine A et al. Dysregulation of the Amniotic PPAR? Pathway by Phthalates: Modulation of the Anti-Inflammatory Activity of PPAR? in Human Fetal Membranes. Life (Basel) 12:N/A (2022). PubMed: 35455039
- Fu J et al. Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR-? to Inhibit the NF-?B/NLRP3 Inflammatory Axis in Spinal Cord Neurons. PPAR Res 2021:6086265 (2021). PubMed: 34484316
- Gantov M et al. Beige adipocytes contribute to breast cancer progression. Oncol Rep 45:317-328 (2021). PubMed: 33416183
- Katoh-Fukui Y et al. Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones. Bone 120:219-231 (2019). PubMed: 30389610
- Wu YX et al. Iguratimod prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator-activated receptor-?. Mol Med Rep 16:8200-8208 (2017). PubMed: 28983607
- Chen X et al. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs. BMC Musculoskelet Disord 18:423 (2017). PubMed: 29073887
- Pinkosky SL et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun 7:13457 (2016). PubMed: 27892461
- Asimakopoulou A et al. Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. Biochim Biophys Acta 1842:1513-24 (2014). PubMed: 25086218