Ro 67-4853，Positive allosteric modulator of mGlu1 (ab120979)

Potent, selective positive allosteric modulator for mGlu₁ (pEC₅₀ = 7.16 for rat mGlu_1a receptors). Increases basal mGluR₁-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC₅₀= 95 nM in CA3 neurons).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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Synthetic

• Neuroscience
• Neurotransmitter
• Amino Acids
• Glutamate

• Neuroscience
• Neurotransmission
• Receptors / Channels
• GPCR
• Glutamate Receptors

• Signal Transduction
• Signaling Pathway
• G Protein Signaling
• GPCR

• Biochemicals
• Chemical Type
• Biochemicals

• Biochemicals
• Pharmacology
• Receptors & Transporters
• Glutamate
• mGlu
• Group I
• Allosteric modulators

• Neuroscience
• Processes