Ro 31-8220 mesylate (Bisindolylmaleimide IX),蛋白kinase抑制剂(ab120374)
Key features and details
- Protein kinase inhibitor
- CAS Number: 138489-18-6
- Purity: > 98%
Soluble in DMSO and organic solvents. Solubility in these solvents is approximately 20 mg/mL.
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Ro 31-8220 mesylate (Bisindolylmaleimide IX),蛋白kinase抑制剂 -
描述
蛋白kinase抑制剂 -
别名
- Bisindolylmaleimide IX
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生物学描述
Widely used as a cell-permeable, reversible, competitive protein kinase C inhibitor. Also potently inhibits wide range of kinases inlcuding RSK1, RSK2, PRK2, PKCα, PKD1, MSK1, GSK3β, CDK2-cyclin A and PIM3, as well as PKCα.
Also available in simple stock solutions (ab146723) - add 1 ml of water to get an exact, ready-to-use concentration. -
纯度
> 98% -
CAS编号
138489-18-6 -
化学结构
性能
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化学名称
3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulfonate
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分子量
553.65 -
PubChem识别号
11628205 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO and organic solvents. Solubility in these solvents is approximately 20 mg/mL.
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处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)O.Cn2cc(c1ccccc12)C=5C(=O)NC(=O)C=5c4cn(CCCSC(=N)N)c3ccccc34 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor (ab120374)2D chemical structure image of ab120374, Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor
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Functional Studies - Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor (ab120374)1.5 x 10e7 THP-1 cells were incubated with 100 nM GF 109203X (ab144264) or Ro 31-8220 mesylate (ab120374) for 30 minutes prior to activation with 10 µg x mL-1 PMA (Sigma) for 4 hours. Control cells were left without inhibitors or PMA. Cells were lysed in 1 mL of lysis buffer, and 30 µL were tested for PKC activity (duplicates; +/- SD).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab120374 被引用在 1 文献中.
- Li Y et al. A novel perspective and approach to intestinal octreotide absorption: sinomenine-mediated reversible tight junction opening and its molecular mechanism. Int J Mol Sci 14:12873-92 (2013). PubMed: 23787475