(R)-Baclofen，GABAB激动剂(ab120325)
Key features and details
- Selective GABAB agonist. Active enantiomer.
- CAS Number: 69308-37-8
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
(R)-Baclofen，GABAB激动剂 -
描述
Selective GABAB激动剂. Active enantiomer. -
生物学描述
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CAS编号
69308-37-8 -
化学结构
性能
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化学名称
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid -
分子量
213.66 -
分子式
C10H12ClNO2 -
PubChem识别号
44602 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(cc1)[C@H](CN)CC(=O)O -
来源
Synthetic
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研究领域
相关产品
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图片
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Chemical Structure - (R)-Baclofen, GABAB agonist (ab120325)2D chemical structure image of ab120325, (R)-Baclofen, GABAB agonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120325 被引用在 4 文献中.
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Llamosas N et al. Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons. Physiol Rep 5:N/A (2017). PubMed: 28196855
- Beckley JT et al. Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. J Neurosci 33:804-13 (2013). PubMed: 23303956
- Wang X et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol 79:758-67 (2011). PubMed: 21189269