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AB120507

(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT)，5-HT1A receptor激动剂

(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist

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(1 Publication)

MW 328.29 Da, Purity >98%. Selective full 5-HT1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT1A. Also displays moderate affinity at 5-HT7. Inhibits amphetamine induced dopamine release.

查看别名

5 hydroxytryptamine 1A receptor, ADRB2RL1, ADRBRL1, G-21, Serotonin receptor 1A

1 Images
Chemical Structure - (R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist (AB120507)
  • Chemical Structure

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Chemical Structure - (R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist (AB120507)

2D chemical structure image of ab120507, (R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist

关键信息

CAS 号

78095-19-9

纯度

>98%

形式

Solid

form

分子量

328.29 Da

分子式

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>6</sub>BrNO

PubChem

11957570

属性

Synthetic

溶解度

Soluble in water to 20 mM

生化试剂名称

(R)-(+)-8-Hydroxy-DPAT hydrobromide

生物学描述

Selective full 5-HT1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT1A. Also displays moderate affinity at 5-HT7. Inhibits amphetamine induced dopamine release.

经典 SMILES

CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O.Br

同分异构的 SMILES

CCCN(CCC)[C@@H]1CCC2=C(C1)C(=CC=C2)O.Br

InChi

InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1

InChiKey

BATPBOZTBNNDLN-PFEQFJNWSA-N

IUPAC 名

(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide

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搭配使用产品

Biochemicals

AB285422

Sulfo-LC-SPDP

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Biochemicals

AB144587

AP-18, TRPA1 receptor antagonist

Chemical Structure - AP-18, TRPA1 receptor antagonist (AB144587)

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Biochemicals

AB141438

AG 1478, EGF receptor tyrosine kinase inhibitor

Chemical Structure - AG 1478, EGF receptor tyrosine kinase inhibitor (AB141438)

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Primary Antibodies

AB5823

Anti-Histone H4 (symmetric di methyl R3) antibody

BOND RX™ Validated

Western blot - Anti-Histone H4 (symmetric di methyl R3) antibody (AB5823)

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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产品实验方案

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 291:22977-22987 PubMed27605665

2016

HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Wen Qian,Chuan Li,Ai-Ping Jiang,Shengfang Ge,Ping Gu,Xianqun Fan,Tai-Sheng Li,Xia Jin,Jian-Hua Wang,Zhi-Liang Wang
View all publications
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