QX-314 bromide (N-Ethyllidocaine bromide)，Na+ channel blocker (ab120117)
Key features and details
- Na+ channel blocker
- CAS Number: 21306-56-9
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
QX-314 bromide (N-Ethyllidocaine bromide)，Na+ channel blocker -
描述
Na+ channel blocker -
别名
- N-Ethyllidocaine bromide
-
生物学描述
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly.
Also available in simple stock solutions (ab144492) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
21306-56-9 -
化学结构
性能
-
化学名称
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide -
分子量
343.31 -
分子式
C16H27BrN2O -
PubChem识别号
9884487 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
[Br-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC -
来源
Synthetic
-
研究领域
图片
-
Chemical Structure - QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (ab120117)2D chemical structure image of ab120117, QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (14)
ab120117 被引用在 14 文献中.
- Xi K et al. CSMD3 Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice. J Neurosci 43:3949-3969 (2023). PubMed: 37037606
- Tønnesen J et al. Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue. Cell 172:1108-1121.e15 (2018). PubMed: 29474910
- Chu HY et al. Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5 (2017). PubMed: 28910619
- Hsu TT et al. Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways. Cereb Cortex 26:2715-27 (2016). PubMed: 26045570
- Zonouzi M et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci 18:674-82 (2015). PubMed: 25821912