Purmorphamine，Smoothened receptor激动剂(ab120933)
Key features and details
- Smoothened receptor agonist
- CAS Number: 483367-10-8
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Purmorphamine，Smoothened receptor激动剂 -
描述
Smoothened receptor激动剂 -
生物学描述
Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells . When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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纯度
> 98% -
CAS编号
483367-10-8 -
化学结构
性能
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化学名称
9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine -
分子量
520.63 -
分子式
C31H32N6O2 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O1CCN(CC1)c1ccc(cc1)Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Purmorphamine, Smoothened receptor agonist (ab120933)2D chemical structure image of ab120933, Purmorphamine, Smoothened receptor agonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (7)
ab120933 被引用在 7 文献中.
- Chiuso F et al. Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep 24:e55571 (2023). PubMed: 36744302
- Zilocchi M et al. Co-fractionation-mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain. Nat Protoc 18:3918-3973 (2023). PubMed: 37985878
- Malave L et al. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Commun Biol 4:1071 (2021). PubMed: 34552196
- Senatore E et al. The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation. EMBO J 40:e106503 (2021). PubMed: 33934390
- Park SR et al. Sonic Hedgehog, a Novel Endogenous Damage Signal, Activates Multiple Beneficial Functions of Human Endometrial Stem Cells. Mol Ther 28:452-465 (2020). PubMed: 31866117
- Kozielewicz P et al. Structural insight into small molecule action on Frizzleds. Nat Commun 11:414 (2020). PubMed: 31964872
- Cho A et al. An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. Mol Ther 27:1286-1298 (2019). PubMed: 31080015