Procainamide hydrochloride，Sodium channel blocker (ab120955)
Key features and details
- Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor.
- CAS Number: 614-39-1
- Purity: > 99%
- Soluble in water to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Procainamide hydrochloride，Sodium channel blocker -
描述
Sodium channel blocker. Specific DNA methyltransferase 1抑制剂. -
生物学描述
Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.
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纯度
> 99% -
CAS编号
614-39-1 -
化学结构
性能
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化学名称
4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride -
分子量
271.79 -
分子式
C13H21N3O.HCl -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM and in ethanol to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
图片
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Chemical Structure - Procainamide hydrochloride, Sodium channel blocker (ab120955)2D chemical structure image of ab120955, Procainamide hydrochloride, Sodium channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (6)
ab120955 被引用在 6 文献中.
- Caniels TG et al. Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions. Cell Rep Med 4:101003 (2023). PubMed: 37044090
- Willis JR et al. Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity 55:2149-2167.e9 (2022). PubMed: 36179689
- Derking R et al. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike. Cell Rep 35:108933 (2021). PubMed: 33826885
- Seabright GE et al. Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions. Structure 28:897-909.e6 (2020). PubMed: 32433992
- Struwe WB et al. Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen. Cell Rep 24:1958-1966.e5 (2018). PubMed: 30134158
- Hasan SS et al. Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization. Cell Rep 25:3136-3147.e5 (2018). PubMed: 30540945