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AB120476

Pro-myristic acid，Negative control for MiTMAB™ and OcTMAB™

Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™

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Pro-myristic acid (CAS No: 43016-78-0)(ab120476). Negative control molecule for use with MiTMAB™ ab120466 and OcTMAB™ ab120467. Pro-myristic acid is an in vitro inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC50 = 9.2 µM for inhibition of dynamin I GTPase). Although cell-permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC50 = ≥300 µM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB&trade. MW 299.5.

- Larger volume format available upon request.
1 Images
Chemical Structure - Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™ (AB120476)
  • Chemical Structure

Lab

Chemical Structure - Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™ (AB120476)

2D chemical structure image of ab120476, Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™

关键信息

CAS 号

43016-78-0

形式

Liquid

form

分子量

299.5 Da

分子式

C<sub>1</sub><sub>8</sub>H<sub>3</sub><sub>7</sub>NO<sub>2</sub>

PubChem

96645

属性

Synthetic

生化试剂名称

2-(Dimethylamino)ethyl myristate

生物学描述

Negative control molecule for use with MiTMAB™ ab120466 and OcTMAB™ ab120467. Pro-myristic acid is an *in vitro* inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC50 = 9.2 µM for inhibition of dynamin I GTPase). Although cell-permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC50 = ≥300 μM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB™.

经典 SMILES

CCCCCCCCCCCCCC(=O)OCCN(C)C

InChi

InChI=1S/C18H37NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-18(20)21-17-16-19(2)3/h4-17H2,1-3H3

InChiKey

WVTLMDGNANZSAT-UHFFFAOYSA-N

IUPAC 名

2-(dimethylamino)ethyl tetradecanoate

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搭配使用产品

Proteins & Peptides

AB100962

Recombinant Human ECHS1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human ECHS1 protein (His tag N-Terminus) (AB100962)

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Primary Antibodies

AB315396

Anti-Plasma Kallikrein 1B antibody [RM2034]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plasma Kallikrein 1B antibody [RM2034] (AB315396)

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Primary Antibodies

AB99887

Anti-TNS4/CTEN antibody [SP83]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TNS4/CTEN antibody [SP83] (AB99887)

  • 5
  • 1
Primary Antibodies

AB10018

Anti-Respiratory Syncytial Virus antibody [9C5]

  • 0
  • 0
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产品详情

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd.
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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产品实验方案

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Abcam Product Promise

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