PNU 120596，Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors (ab120559)
Key features and details
- Positive allosteric modulator for the α7 nicotinic acetylcholine receptor
- CAS Number: 501925-31-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
PNU 120596，Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors -
描述
Positive allosteric modulator for the α7 nicotinic acetylcholine receptor -
生物学描述
Competitive, type II positive allosteric modulator for α7nAChR (EC50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
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CAS编号
501925-31-1 -
化学结构
性能
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化学名称
N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)urea -
分子量
311.72 -
分子式
C13H14ClN3O4 -
PubChem识别号
311434 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors (ab120559)2D chemical structure image of ab120559, PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120559 被引用在 1 文献中.
- Ibrahim AbdEl Fattah L et al. The Effect of Thymoquinone, a7 Receptor Agonist and a7 Receptor Allosteric Modulator on the Cerebral Cortex in Experimentally Induced Alzheimer's Disease in Relation to MSCs Activation. Int J Stem Cells 9:230-238 (2016). Functional Studies . PubMed: 27572711