PK11195，benzodiazepine receptor拮抗剂(ab120378)
Key features and details
- Peripheral benzodiazepine receptor antagonist
- CAS Number: 85532-75-8
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
PK11195，benzodiazepine receptor拮抗剂 -
描述
Peripheral benzodiazepine receptor拮抗剂 -
生物学描述
Antagonist at the mitochondrial (peripheral) benzodiazepine receptor (translocator protein, TSPO). Acts as a chemosensitizer of tumor cells to a wide range of chemotherapeutic agents.
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纯度
> 99% -
CAS编号
85532-75-8 -
化学结构
性能
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化学名称
N-sec-Butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide -
分子量
352.86 -
分子式
C21H21ClN2O -
PubChem识别号
1345 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(CC)N(C)C(=O)c2cc1ccccc1c(n2)c3ccccc3Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - PK11195, benzodiazepine receptor antagonist (ab120378)2D chemical structure image of ab120378, PK11195, benzodiazepine receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120378 被引用在 2 文献中.
- Luo A et al. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. J Transl Med 21:71 (2023). PubMed: 36732752
- Walker MD et al. [11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat. J Cereb Blood Flow Metab 35:1331-8 (2015). PubMed: 25833342