Pitstop® 2 - negative control，Negative control for clathrin抑制剂Pitstop®2 (ab120688)
Key features and details
- Negative control for clathrin inhibitor Pitstop® 2 (ab120687)
- CAS Number: 1576239-29-6
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Pitstop® 2 - negative control，Negative control for clathrin抑制剂Pitstop®2 -
描述
Negative control for clathrin抑制剂Pitstop® 2 (ab120687) -
生物学描述
Negative control for clathrin inhibitor Pitstop® 2 (ab120687) which is of the same chemical class and has a highly related structure to Pitstop® 2. Inhibits amphiphysin binding to the clathrin TD with an IC50 >100 μM and does not block receptor-mediated endocytosis at concentrations of up to 300 μM (unpublished reports).
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纯度
> 99% -
常规说明
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute -
CAS编号
1576239-29-6 -
化学结构
性能
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化学名称
5-(4-Bromobenzylidene)-2-(naphthalen-1-ylamino)-1,3-thiazol-4(5H)-one -
分子量
409.30 -
分子式
C20H13BrN2OS -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
图片
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Chemical Structure - Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop® 2 (ab120688)2D chemical structure image of ab120688, Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop®2
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (15)
ab120688 被引用在 15 文献中.
- Králová J et al. Sterolight as imaging tool to study sterol uptake, trafficking and efflux in living cells. Sci Rep 12:6264 (2022). PubMed: 35428843
- Abu Rass R et al. Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification. Front Cell Dev Biol 10:1075364 (2022). PubMed: 36605723
- Abdul-Salam VB et al. CLIC4/Arf6 Pathway. Circ Res 124:52-65 (2019). PubMed: 30582444
- Martínez-Muñoz L et al. Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function. Mol Cell 70:106-119.e10 (2018). PubMed: 29625032
- Albecka A et al. HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis. Traffic 17:21-39 (2016). PubMed: 26459807
