Pirenzepine dihydrochloride，M1拮抗剂(ab120153)
Key features and details
- M1 antagonist
- CAS Number: 29868-97-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Pirenzepine dihydrochloride，M1拮抗剂 -
描述
M1拮抗剂 -
生物学描述
Selective M1 receptor antagonist.
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CAS编号
29868-97-1 -
化学结构
性能
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化学名称
5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride -
分子量
424.32 -
分子式
C19H21N5O2.2HCl -
PubChem识别号
71405 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.O=C(CN1CCN(C)CC1)N4c2ccccc2C(=O)Nc3cccnc34 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Pirenzepine dihydrochloride, M1 antagonist (ab120153)2D chemical structure image of ab120153, Pirenzepine dihydrochloride, M1 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120153 被引用在 4 文献中.
- Hu NW et al. mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo. Nat Commun 5:3374 (2014). PubMed: 24594908
- Barrett SG & Chapman CA Contribution of muscarinic M1 receptors to the cholinergic suppression of synaptic responses in layer II of the entorhinal cortex. Neurosci Lett 554:11-5 (2013). PubMed: 24012918
- Glasgow SD et al. Cholinergic suppression of excitatory synaptic transmission in layers II/III of the parasubiculum. Neuroscience 201:1-11 (2012). PubMed: 22138154
- Gorini C et al. Endogenous inhibition of the trigeminally evoked neurotransmission to cardiac vagal neurons by muscarinic acetylcholine receptors. J Neurophysiol 104:1841-8 (2010). PubMed: 20719927