Picrotoxin，GABAA拮抗剂(ab120315)
Key features and details
- GABAA antagonist
- CAS Number: 124-87-8
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
- Form / State: Solid
- Source: Anamirta cocculus
概述
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产品名称
Picrotoxin，GABAA拮抗剂 -
描述
GABAA拮抗剂 -
生物学描述
Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant in vivo.
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常规说明
5g pack supplied as 5x1g
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CAS编号
124-87-8 -
化学结构
性能
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化学名称
1:1 mixture of picrotoxinin and picrotin -
分子量
602.59 -
分子式
C30H34O13 -
PubChem识别号
31304 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=C)[C@@H]1C2[C@@H]3[C@@]4([C@](C1C(=O)O2)(CC5[C@]4(O5)C(=O)O3)O)C.C[C@@]12[C@H]3C4[C@H](C([C@@]1(C[C@@H]5[C@]2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O -
来源
Anamirta cocculus
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研究领域
图片
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Chemical Structure - Picrotoxin, GABAA antagonist (ab120315)2D chemical structure image of ab120315, Picrotoxin, GABAA antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (80)
ab120315 被引用在 80 文献中.
- Oh H et al. Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nat Commun 14:3547 (2023). PubMed: 37321992
- Chou MY et al. Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice. Commun Biol 6:267 (2023). PubMed: 36918719
- Dyer MS et al. Synaptic remodeling follows upper motor neuron hyperexcitability in a rodent model of TDP-43. Front Cell Neurosci 17:1274979 (2023). PubMed: 37941604
- Gonzalez JC et al. Circadian regulation of dentate gyrus excitability mediated by G-protein signaling. Cell Rep 42:112039 (2023). PubMed: 36749664
- Clark RM et al. Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice. Ann Clin Transl Neurol 10:1985-1999 (2023). PubMed: 37644692