Philanthotoxin-7,4 (PhTx-74)，GluA1/GluA2 (formerly GluR1/2)抑制剂(ab120257)
Key features and details
- GluA1/GluA2 (formerly GluR1/2) inhibitor
- CAS Number: 401601-12-5
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Philanthotoxin-7,4 (PhTx-74)，GluA1/GluA2 (formerly GluR1/2)抑制剂 -
描述
GluA1/GluA2 (formerly GluR1/2)抑制剂 -
别名
- PhTx-74
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生物学描述
Selective, calcium-permeable AMPA receptor antagonist. Inhibits GluA1/A2 (formerly GluR1/2), with little activity at GluA2/A3 (formerly GluR2/3)
Also available in simple stock solutions (ab146706) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
401601-12-5 -
化学结构
性能
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化学名称
(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride -
分子量
507.54 -
分子式
C24H42N4O3.2HCl -
PubChem识别号
46213501 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.Oc1ccc(C[C@H](NC(=O)CCC)C(=O)NCCCCCCCNCCCCN)cc1 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Philanthotoxin-7,4 (PhTx-74), GluA1/GluA2 (formerly GluR1/2) inhibitor (ab120257)2D chemical structure image of ab120257, Philanthotoxin-7,4 (PhTx-74), GluA1/GluA2 (formerly GluR1/2) inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120257 被引用在 2 文献中.
- Li XR et al. Acetylation-dependent glutamate receptor GluR signalosome formation for STAT3 activation in both transcriptional and metabolism regulation. Cell Death Discov 7:11 (2021). PubMed: 33446662
- Li Y et al. A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats. Neurosci Bull 37:669-683 (2021). PubMed: 33779892