PHCCC，allosteric potentiator at mGlu4 (ab120043)
Key features and details
- Selective allosteric potentiator at mGlu4. Also group I antagonist.
- CAS Number: 179068-02-1
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
PHCCC，allosteric potentiator at mGlu4 -
描述
Selective allosteric potentiator at mGlu4. Also group I拮抗剂. -
生物学描述
Selective allosteric potentiator of mGlu4. Anti-Parkinson and anxiolytic effects in vivo. Also antagonist at Group I metabotropic receptors.
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CAS编号
179068-02-1 -
化学结构
性能
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化学名称
(E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
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分子量
294.31 -
分子式
C17H14N2O3 -
PubChem识别号
5866327 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM
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处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
ON=C1c4ccccc4OC2(CC12)C(=O)Nc3ccccc3 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - PHCCC, allosteric potentiator at mGlu4 (ab120043)2D chemical structure image of ab120043, PHCCC, allosteric potentiatorat mGlu4
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120043 被引用在 3 文献中.
- Yin S et al. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34:79-94 (2014). PubMed: 24381270
- Gosnell HB et al. mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology 36:1599-607 (2011). PubMed: 21451497
- Goudet C et al. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain 137:112-24 (2008). PubMed: 17900808