Paroxetine hydrochloride，5-HT uptake抑制剂(ab120069)
Key features and details
- 5-HT uptake inhibitor
- CAS Number: 110429-35-1
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Paroxetine hydrochloride，5-HT uptake抑制剂 -
描述
5-HT uptake抑制剂 -
生物学描述
Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
-
CAS编号
110429-35-1 -
化学结构
性能
-
化学名称
(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride -
分子量
365.83 -
分子式
C19H20FNO3.HCl -
PubChem识别号
62878 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl -
来源
Synthetic
-
研究领域
图片
-
Chemical Structure - Paroxetine hydrochloride, 5-HT uptake inhibitor (ab120069)2D chemical structure image of ab120069, Paroxetine hydrochloride, 5-HT uptake inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120069 被引用在 4 文献中.
- Collins HM et al. Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation. Psychopharmacology (Berl) 240:2403-2418 (2023). PubMed: 37584734
- Collins HM et al. Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice. J Psychopharmacol 36:794-805 (2022). PubMed: 35607713
- Toulme E et al. P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol 135:333-53 (2010). PubMed: 20231374
- Mongeau R et al. 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment. J Neurochem 115:438-49 (2010). PubMed: 20796171