Ouabain octahydrate，Na+/K+ ATPase抑制剂(ab120748)
Key features and details
- Na+/K+ ATPase inhibitor
- CAS Number: 11018-89-6
- Purity: > 97%
- Soluble in DMSO to 100 mM, in ethanol to 10 mM and in water to 10 mM.
- Form / State: Solid
- Source: ripe seeds of African plants Strophanthus gratus and the bark of Acokanthera ouabaio
概述
-
产品名称
Ouabain octahydrate，Na+/K+ ATPase抑制剂 -
描述
Na+/K+ ATPase抑制剂 -
生物学描述
Na+/K+ ATPase inhibitor (Ki = 30 μM). Cardiac glycoside. Stimulates activity at low nanomolar concentrations in rats. Improves cardiac function in myocardial infarction rats. Centrally active following oral administration.
-
纯度
> 97% -
常规说明
It has been reported that an aqueous solution of this material stored overnight in a borosilicate glass vial leads to the formation of ouabain-borate complexes.
It is therefore recommended that this material is stored in a plastic vial and any contact with borosilicate glass is minimised. -
CAS编号
11018-89-6 -
化学结构
性能
-
化学名称
(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide -
分子量
728.78 -
分子式
C29H44O12.8H2O -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM, in ethanol to 10 mM and in water to 10 mM. -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
来源
ripe seeds of African plants Strophanthus gratus and the bark of Acokanthera ouabaio
-
研究领域
图片
-
Chemical Structure - Ouabain octahydrate, Na+/K+ ATPase inhibitor (ab120748)2D chemical structure image of ab120748, Ouabain octahydrate, Na+/K+ ATPase inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120748 被引用在 1 文献中.
- Zhao J et al. Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase. Nat Commun 13:7136 (2022). PubMed: 36414629