NS309, K+ channel activator

关键信息

纯度

>98%

形式

Solid

form

分子量

231.03 Da

分子式

C₈H₄Cl₂N₂O₂

PubChem

11637204

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生化试剂名称

CID 11637204

生物学描述

Potent activator of human Ca2+ -activated K+ channels of SK and IK types, selective over BK type channels (EC50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO (ab120258). Can be used in conjunction with CyPPA (ab120829) to distinguish SK1 and SK3 subtypes.

经典 SMILES

C1=CC(=C(C2=NC(=O)C(=C21)NO)Cl)Cl

同分异构的 SMILES

C1=CC(=C(C2=NC(=O)C(=C21)NO)Cl)Cl

InChi

InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

InChiKey

CVOUSAVHMDXCKG-UHFFFAOYSA-N

IUPAC 名

6,7-dichloro-3-(hydroxyamino)indol-2-one