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AB141521

NPPB，chloride channel blocker

NPPB, chloride channel blocker

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MW 300.31 Da, Purity >99%. Potent chloride channel blocker (IC50 = 80 nM). GPR35 agonist. Able to uncouple mitochondria. Active in vivo.

查看别名

(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, AI413597, AW045860, CP2C9_HUMAN, CPC9, CYP2C, CYP2C10, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450, family 2, subfamily C, polypeptide 9, DDPAC, FLJ31424, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, MAPT, MAPTL, MGC134287, MGC138549, MGC149605, MGC156663, MGC88320, MSTD, MTBT1, MTBT2, Microsomal monooxygenase, Microtubule associated protein tau isoform 4, Microtubule-associated protein tau, Mtapt, Neurofibrillary tangle protein, OTTHUMP00000020135, P450 MP, P450 PB 1, P450IIC9, PHF-tau, PPND, PPP1R103, Paired helical filament-tau, Protein phosphatase 1, regulatory subunit 103, RNPTAU, S-mephenytoin 4-hydroxylase, TAU_HUMAN, Tauopathy and respiratory failure, Tauopathy and respiratory failure, included, Xenobiotic monooxygenase, cytochrome P-450 S-mephenytoin 4-hydroxylase, flavoprotein-linked monooxygenase, pTau

1 Images
Chemical Structure - NPPB, chloride channel blocker (AB141521)
  • Chemical Structure

Lab

Chemical Structure - NPPB, chloride channel blocker (AB141521)

2D chemical structure image of ab141521, NPPB, chloride channel blocker

关键信息

CAS 号

107254-86-4

纯度

>99%

形式

Solid

form

分子量

300.31 Da

分子式

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

4549

属性

Synthetic

溶解度

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

生化试剂名称

5-Nitro-2-(3-phenylpropylamino)benzoic acid

生物学描述

Potent chloride channel blocker (IC50 = 80 nM). GPR35 agonist. Able to uncouple mitochondria. Active in vivo.

经典 SMILES

C1=CC=C(C=C1)CCCNC2=C(C=C(C=C2)[N+](=O)[O-])C(=O)O

InChi

InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

InChiKey

WBSMIPAMAXNXFS-UHFFFAOYSA-N

IUPAC 名

5-nitro-2-(3-phenylpropylamino)benzoic acid

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
The product can be stored for up to 12 months
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tau protein also known as MAPT (Microtubule Associated Protein Tau) is a microtubule-associated protein primarily found in neurons. It plays an important role in stabilizing microtubules part of the cytoskeletal structure. The protein has a molecular mass of around 58 kDa to 79 kDa depending on its isoform. Tau is predominantly expressed in the central nervous system but can also appear in other tissues such as peripheral nervous system cells in smaller amounts.
Biological function summary

Tau protein significantly contributes to the maintenance and stabilization of neuronal microtubules supporting axonal transport. In its functional state Tau binds to microtubules and assists in their assembly. Tau can undergo several post-translational modifications which can affect its binding efficiency and stability. Despite being a single protein Tau interacts extensively with other cytoskeletal elements closely influencing cellular architecture and function.

Pathways

Tau protein integrates into important signaling pathways such as the MAPK (mitogen-activated protein kinase) pathway and the PI3K/AKT pathway. These pathways influence cell growth survival and differentiation. Tau can phosphorylate through these pathways altering its interaction with microtubules. The protein also collaborates with other cytoskeletal proteins and kinases within these pathways particularly influencing neuronal signaling and structure.

Tau protein is closely associated with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. In these disorders abnormal hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles disrupting normal neuron function. The connection with Alzheimer's disease is prominent seeing its relationship with Amyloid-beta which also plays a role in disease pathogenesis. Tau's malfunction can therefore heavily impact neurological health reinforcing the protein's central role in neurodegenerative diseases.
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产品实验方案

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搭配使用产品

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Reagents, Controls & Accessories

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