nor-Binaltorphimine (nor-BNI)，kappa opioid receptor拮抗剂(ab120078)
Key features and details
- Potent and selective κ opioid receptor antagonist
- CAS Number: 113158-34-2
- Purity: > 98%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
nor-Binaltorphimine (nor-BNI)，kappa opioid receptor拮抗剂 -
描述
Potent and selective κ opioid receptor拮抗剂 -
别名
- nor-BNI
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生物学描述
Potent and selective κ opioid receptor antagonist
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纯度
> 98% -
CAS编号
113158-34-2 -
化学结构
性能
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化学名称
17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino-7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride -
分子量
734.72 -
分子式
C40H43N3O6.2HCl -
PubChem识别号
11957626 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (ab120078)2D chemical structure image of ab120078, nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (12)
ab120078 被引用在 12 文献中.
- Xu C et al. The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice. J Mol Neurosci 74:3 (2024). PubMed: 38183534
- Wang YJ et al. The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology. Nat Commun 14:7903 (2023). PubMed: 38036497
- Karaki F et al. Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol. Molecules 28:N/A (2023). PubMed: 37836768
- Makino Y et al. Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1. Commun Biol 5:299 (2022). PubMed: 35365763
- Huang H et al. Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. Pain Res Manag 2022:4819910 (2022). PubMed: 35646201
