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AB120078

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

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(14 Publications)

Norbinaltorphimine dihydrochloride/nor-Binaltorphimine (ab120078) is a potent and selective kappa opioid receptor antagonist. MW 734.7, Purity >98%.

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Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)
  • Chemical Structure

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Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

2D chemical structure image of ab120078, nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

关键信息

CAS 号

113158-34-2

纯度

>98%

形式

Solid

form

分子量

734.7 Da

分子式

C<sub>4</sub><sub>0</sub>H<sub>4</sub><sub>5</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>6</sub>

PubChem

11957626

属性

Synthetic

溶解度

Soluble in water to 50 mM

生化试剂名称

nor-Binaltorphimine dihydrochloride

生物学描述

Potent and selective κ opioid receptor antagonist

经典 SMILES

C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl

同分异构的 SMILES

C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl

InChi

InChI=1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChiKey

JOJPJLHRMGPDPV-LZQROVCBSA-N

IUPAC 名

(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol;dihydrochloride

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产品详情

Check out our range of opioid antagonist biochemicals here
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months
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产品实验方案

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文献 (14)

Recent publications for all applications. Explore the full list and refine your search

BMC nephrology 26:307 PubMed40596915

2025

Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia-reperfusion-induced acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroto Takeuchi,Satoshi Tatemichi,Yuji Okuhara

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 21:e00377 PubMed38777742

2024

A synthetic peptide exerts nontolerance-forming antihyperalgesic and antidepressant effects in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjiang Wu,Xiaofei Song,YanZhe Ji,Gang Chen,Long Zhao

Journal of molecular neuroscience : MN 74:3 PubMed38183534

2024

The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chi Xu,Jiayu Ye,Yanting Sun,Xiujian Sun,Jing-Gen Liu

Nature communications 14:7903 PubMed38036497

2023

The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Jun Wang,Gui-Ying Zan,Cenglin Xu,Xue-Ping Li,Xuelian Shu,Song-Yu Yao,Xiao-Shan Xu,Xiaoyun Qiu,Yexiang Chen,Kai Jin,Qi-Xin Zhou,Jia-Yu Ye,Yi Wang,Lin Xu,Zhong Chen,Jing-Gen Liu

Molecules (Basel, Switzerland) 28: PubMed37836768

2023

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol.

Applications

Unspecified application

Species

Unspecified reactive species

Fumika Karaki,Taro Takamori,Koumei Kawakami,Sae Sakurai,Kyoko Hidaka,Kei Ishii,Tomoya Oki,Noriko Sato,Nao Atsumi,Karin Ashizawa,Ai Taguchi,Asuka Ura,Toko Naruse,Shigeto Hirayama,Miki Nonaka,Kanako Miyano,Yasuhito Uezono,Hideaki Fujii

Journal of leukocyte biology 112:1317-1328 PubMed36205434

2022

Morphine disrupts macrophage functions even during HIV infection.

Applications

Unspecified application

Species

Unspecified reactive species

John M Barbaro,Matias Jaureguiberry-Bravo,Simone Sidoli,Joan W Berman

Pain research & management 2022:4819910 PubMed35646201

2022

Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Huiying Huang,Xiaohui Bai,Kun Zhang,Jin Guo,Shaoyong Wu,Handong Ouyang

Neuroscience bulletin 38:403-416 PubMed35397112

2022

Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain.

Applications

Unspecified application

Species

Unspecified reactive species

Fu-Jun Zhai,Song-Ping Han,Tian-Jia Song,Ran Huo,Xing-Yu Lan,Rong Zhang,Ji-Sheng Han

Communications biology 5:299 PubMed35365763

2022

Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Makino,Yuki Kamiyama,J B Brown,Toshiya Tanaka,Ryusuke Murakami,Yuki Teramoto,Takayuki Goto,Shusuke Akamatsu,Naoki Terada,Takahiro Inoue,Tatsuhiko Kodama,Osamu Ogawa,Takashi Kobayashi

Acta pharmacologica Sinica 43:1372-1382 PubMed34493813

2021

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan-Yuan Wei,Yan Ma,Song-Yu Yao,Ling-Hui Kong,Xiao Liu,Jing-Rui Chai,Jing Chen,Wei Li,Yu-Jun Wang,Li-Ming Shao,Jing-Gen Liu
View all publications
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