NNC 711，GAT-1抑制剂(ab120364)
Key features and details
- Potent, selective GAT-1 inhibitor
- CAS Number: 145645-62-1
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
NNC 711，GAT-1抑制剂 -
描述
Potent，selective GAT-1抑制剂 -
生物学描述
Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.
Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
145645-62-1 -
化学结构
性能
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化学名称
1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride -
分子量
386.88 -
分子式
C21H22N2O3.HCl -
PubChem识别号
123738 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C(O)C=3CN(CCON=C(/c1ccccc1)c2ccccc2)CCC=3 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - NNC 711, GAT-1 inhibitor (ab120364)2D chemical structure image of ab120364, NNC 711, GAT-1 inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120364 被引用在 1 文献中.
- Romo-Parra H et al. Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice. J Neurophysiol 113:3421-31 (2015). PubMed: 25787948