Nitrendipine，L-type Ca2+ channel blocker (ab120139)
Key features and details
- L-type Ca2+ channel blocker
- CAS Number: 39562-70-4
- Soluble in DMSO to 50 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Nitrendipine，L-type Ca2+ channel blocker -
描述
L-type Ca2+ channel blocker -
生物学描述
L-type Ca2+ channel blocker. Antihypertensive in vivo.
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CAS编号
39562-70-4 -
化学结构
性能
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化学名称
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester -
分子量
360.36 -
分子式
C18H20N2O6 -
PubChem识别号
4507 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 50 mM and in ethanol to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC=1NC(C)=C(C(C=1C(=O)OCC)c2cccc(c2)[N+]([O-])=O)C(=O)OC -
来源
Synthetic
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研究领域
- Cell Biology
- Proteolysis / Ubiquitin
- Proteasome / Ubiquitin
- Ubiquitin E3 Enzymes
- RING Finger E3 Ligase
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120139于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Nitrendipine, L-type Ca2+ channel blocker (ab120139)2D chemical structure image of ab120139, Nitrendipine, L-type Ca2+ channel blocker
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Functional Studies - Nitrendipine, L-type Ca2+ channel blocker (ab120139)ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nitrendipine (ab120139), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nitrendipine, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120139 (nitrendipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab120139 尚未被引用在任何文献中。