AB120135

Nifedipine, L-type Ca2+ channel blocker

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(14 Publications)

MW 346.3 Da, Purity >99%. L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.

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Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (AB120135)

Chemical Structure

Lab

Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (AB120135)

2D chemical structure image of ab120135, Nifedipine, L-type Ca2+ channel blocker

Functional Studies - Nifedipine, L-type Ca2+ channel blocker (AB120135)

FuncS

Unknown

Functional Studies - Nifedipine, L-type Ca2+ channel blocker (AB120135)

ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nifedipine (ab120135), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nifedipine, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120135 (nifedipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight^® 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

关键信息

CAS 号

21829-25-4

纯度

>99%

形式

Solid

form

分子量

346.3 Da

分子式

C17H18N2O6

PubChem

4485

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生化试剂名称

Nifedipine

生物学描述

L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.

经典 SMILES

CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

InChi

InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

InChiKey

HYIMSNHJOBLJNT-UHFFFAOYSA-N

IUPAC 名

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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文献 (14)

Recent publications for all applications. Explore the full list and refine your search

ACS pharmacology & translational science 7:236-248 PubMed38230281

2024

Optogenetic Activation of Peripheral Somatosensory Neurons in Transgenic Mice as a Neuropathic Pain Model for Assessing the Therapeutic Efficacy of Analgesics.

Applications

Unspecified application

Species

Unspecified reactive species

Hao-Hao Chen,Muhammad Mohsin,Jia-Yi Ge,Yu-Ting Feng,Jing-Ge Wang,Yu-Sen Ou,Zuo-Jie Jiang,Bo-Ya Hu,Xing-Jun Liu

Cell stem cell 30:86-95.e4 PubMed36563695

2022

A deep learning platform to assess drug proarrhythmia risk.

Applications

Unspecified application

Species

Unspecified reactive species

Ricardo Serrano,Dries A M Feyen,Arne A N Bruyneel,Anna P Hnatiuk,Michelle M Vu,Prashila L Amatya,Isaac Perea-Gil,Maricela Prado,Timon Seeger,Joseph C Wu,Ioannis Karakikes,Mark Mercola

iScience 25:104436 PubMed35707725

2022

Phototransduction in a marine sponge provides insights into the origin of animal vision.

Applications

Unspecified application

Species

Unspecified reactive species

Eunice Wong,Victor Anggono,Stephen R Williams,Sandie M Degnan,Bernard M Degnan

Frontiers in cellular neuroscience 13:569 PubMed31998078

2020

Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.

Applications

Unspecified application

Species

Unspecified reactive species

Tongtong Wang,Xin Ye,Wei Bian,Zhichi Chen,Juanjuan Du,Mengyi Li,Peng Zhou,Huairui Cui,Yu-Qiang Ding,Shuangshuang Qi,Min Liao,Chenyou Sun

Scientific reports 7:9357 PubMed28839233

2017

Optogenetic regulation of insulin secretion in pancreatic β-cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Zhang,Emmanuel S Tzanakakis

Neuron 95:639-655.e10 PubMed28712654

2017

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.

Applications

Unspecified application

Species

Unspecified reactive species

Emilia Favuzzi,André Marques-Smith,Rubén Deogracias,Christian M Winterflood,Alberto Sánchez-Aguilera,Laura Mantoan,Patricia Maeso,Cathy Fernandes,Helge Ewers,Beatriz Rico

Molecular biology of the cell 27:3329-3341 PubMed27605709

2016

Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters.

Applications

Unspecified application

Species

Unspecified reactive species

Trine Lisberg Toft-Bertelsen,Iwona Ziomkiewicz,Sébastien Houy,Paulo S Pinheiro,Jakob B Sørensen

Neurobiology of aging 36:730-9 PubMed25443285

2014

Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Tariq Ahmed,David Blum,Sylvie Burnouf,Dominique Demeyer,Valérie Buée-Scherrer,Rudi D'Hooge,Luc Buée,Detlef Balschun

The Journal of physiology 592:3537-57 PubMed24907304

2014

Depression biased non-Hebbian spike-timing-dependent synaptic plasticity in the rat subiculum.

Applications

Unspecified application

Species

Unspecified reactive species

Anurag Pandey,Sujit Kumar Sikdar

Proceedings of the National Academy of Sciences of 111:4303-8 PubMed24550458

2014

Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Federico Brandalise,Urs Gerber

View all publications

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Nifedipine, L-type Ca2+ channel blocker