Nicotinamide，PARP抑制剂(ab120864)
Key features and details
- Amide form of vitamin B3
- CAS Number: 98-92-0
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Nicotinamide，PARP抑制剂 -
描述
Amide form of vitamin B3 -
生物学描述
Amide form of vitamin B3. Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD+). Essential for the synthesis of NAD+ phosphate (NADP+). Essential for energy metabolism, normal physiology and disease progression. Associated with a number of signaling pathways including oxidative stress, cell survival and inflammation. These effects are orchestrated partly through forkhead, Akt, Bad, caspase, MAPK and PARP signaling. Non-selective sirtuin inhibitor. Commonly used as 3D growth matrix components and additive for long-term growth.
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纯度
> 99% -
CAS编号
98-92-0 -
化学结构
性能
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化学名称
Pyridine-3-carboxamide -
分子量
122.13 -
分子式
C6H6N2O -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
图片
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Chemical Structure - Nicotinamide, PARP inhibitor (ab120864)2D chemical structure image of ab120864, Nicotinamide, PARP inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120864 被引用在 4 文献中.
- Huang X et al. Ginsenoside Rk2 Protects against Ulcerative Colitis via Inactivating ERK/MEK Pathway by SIRT1. J Environ Pathol Toxicol Oncol 41:89-98 (2022). PubMed: 35695654
- Adamkova K et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol 8:83 (2017). PubMed: 29118980
- Zou D et al. Correction: Protective Effects of Myricetin on Acute Hypoxia-Induced Exercise Intolerance and Mitochondrial Impairments in Rats. PLoS One 10:e0133336 (2015). PubMed: 26176666
- Zou D et al. Protective effects of myricetin on acute hypoxia-induced exercise intolerance and mitochondrial impairments in rats. PLoS One 10:e0124727 (2015). PubMed: 25919288