NBQX disodium salt，AMPA / kainate拮抗剂(ab120046)
Key features and details
- AMPA / kainate antagonist; water soluble
- CAS Number: 479347-86-9
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
NBQX disodium salt，AMPA / kainate拮抗剂 -
描述
AMPA / kainate拮抗剂; water soluble -
生物学描述
Water soluble, potent, selective and competitive AMPA / kainate receptor antagonist. Neuroprotective and anticonvulsant in vivo.
Also available in simple stock solutions (ab144489) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
479347-86-9 -
化学结构
性能
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化学名称
2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt -
分子量
380.24 -
分子式
C12H6N4Na2O6S -
PubChem识别号
3272523 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Na+].[Na+].NS(=O)(=O)c3cccc2c3c(cc1nc([O-])c([O-])nc12)[N+]([O-])=O -
来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120046于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - NBQX disodium salt, AMPA / kainate antagonist (ab120046)2D chemical structure image of ab120046, NBQX disodium salt, AMPA / kainate antagonist
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Functional Studies - NBQX disodium salt, AMPA / kainate antagonist (ab120046)ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with NBQX disodium salt (ab120046), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of NBQX disodium salt, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120046 (NBQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (67)
ab120046 被引用在 67 文献中.
- Tasnim A et al. The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders. Nat Neurosci 27:484-496 (2024). PubMed: 38233682
- Boyle KA et al. Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling. Elife 12:N/A (2023). PubMed: 37490401
- Park H et al. PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease. Cell 185:1943-1959.e21 (2022). PubMed: 35545089
- Bellusci L et al. Interactions between Brainstem Neurons That Regulate the Motility to the Stomach. J Neurosci 42:5212-5228 (2022). PubMed: 35610046
- Monday HR et al. Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals. Neuron 110:2588-2606.e6 (2022). PubMed: 35728596