Nafadotride，D3拮抗剂(ab120742)
Key features and details
- Potent, selective D3 antagonist
- CAS Number: 149649-22-9
- Purity: > 99%
- Soluble in 1eq. HCl to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Nafadotride，D3拮抗剂 -
描述
Potent，selective D3拮抗剂 -
生物学描述
Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).
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纯度
> 99% -
CAS编号
149649-22-9 -
化学结构
性能
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化学名称
N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide -
分子量
365.47 -
分子式
C22H27N3O2 -
PubChem识别号
3408722 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in 1eq. HCl to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCN3CCC[C@H]3CNC(=O)c2cc(C#N)c1ccccc1c2OC -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Nafadotride, D3 antagonist (ab120742)2D chemical structure image of ab120742, Nafadotride, D3 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120742 被引用在 3 文献中.
- Kohnomi S et al. D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell. J Neurophysiol 107:692-703 (2012). PubMed: 22049335
- Banasikowski TJ et al. Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats. Behav Pharmacol 23:89-97 (2012). PubMed: 22157177
- Sautel F et al. Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther 275:1239-46 (1995). PubMed: 8531087