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AB120742

Nafadotride,D3拮抗剂

Nafadotride, D3 antagonist

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(3 Publications)

Nafadotride (CAS No: 149649-22-9)(ab120742). Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)). MW 365.5. Purity >99%.

- Larger volume format available upon request.

查看别名

2700049B16Rik, 3110031N04Rik, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, CAPC, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cytokeratin-associated protein in cancer, D(2) dopamine receptor, D(3) dopamine receptor, Dopamine D2 receptor, Dopamine D3 receptor, Drosophila slowpoke like, Hbeta1, Hbeta2, Hbeta3, Hbeta4, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MGC22431, MGC57945, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, SAKCA, SLO, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, bA350O14.10, cytokeratin-associated protein, hSlo, hslo beta, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4

1 Images
Chemical Structure - Nafadotride, D3 antagonist (AB120742)
  • Chemical Structure

Lab

Chemical Structure - Nafadotride, D3 antagonist (AB120742)

2D chemical structure image of ab120742, Nafadotride, D3 antagonist

关键信息

CAS 号

149649-22-9

纯度

>99%

形式

Solid

form

分子量

365.5 Da

分子式

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>7</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

3408722

属性

Synthetic

溶解度

Soluble in 1eq. HCl to 50 mM

生化试剂名称

Nafadotride

生物学描述

Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).

经典 SMILES

CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC

InChi

InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)

InChiKey

IDZASIQMRGPBCQ-UHFFFAOYSA-N

IUPAC 名

N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide

性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

产品实验方案

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Behavioural pharmacology 23:89-97 PubMed22157177

2011

Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Tomek J Banasikowski,Lindsey S MacLeod,Richard J Beninger

Journal of neurophysiology 107:692-703 PubMed22049335

2011

D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.

Applications

Unspecified application

Species

Unspecified reactive species

Shuntaro Kohnomi,Noriaki Koshikawa,Masayuki Kobayashi

The Journal of pharmacology and experimental therapeutics 275:1239-46 PubMed8531087

1995

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

Applications

Unspecified application

Species

Unspecified reactive species

F Sautel,N Griffon,P Sokoloff,J C Schwartz,C Launay,P Simon,J Costentin,A Schoenfelder,F Garrido,A Mann
View all publications

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