N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME)，NOS抑制剂(ab120136)
Key features and details
- NOS inhibitor
- CAS Number: 51298-62-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME)，NOS抑制剂 -
描述
NOS抑制剂 -
别名
- L-NAME
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生物学描述
Cell-permeable NOS inhibitor. More soluble analog of arginine. (pIC50 values are 4.3, 5.7 and 5.6 at human iNOS, nNOA and eNOS, respectively).
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CAS编号
51298-62-5 -
化学结构
性能
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化学名称
Nω-Nitro-L-arginine methyl ester hydrochloride -
分子量
269.69 -
分子式
C7H15N5O4.HCl -
PubChem识别号
135193 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(=O)OC -
来源
Synthetic
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研究领域
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
图片
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Chemical Structure - N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor (ab120136)2D chemical structure image of ab120136, N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (10)
ab120136 被引用在 10 文献中.
- Aboouf MA et al. Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT. Front Oncol 12:976961 (2022). PubMed: 36052260
- Boulghobra D et al. Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection. Basic Res Cardiol 116:66 (2021). PubMed: 34940922
- Pal S et al. Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs. Bone 135:115305 (2020). PubMed: 32126313
- Liu W et al. Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex. Front Psychiatry 11:837 (2020). PubMed: 33088274
- Ren H et al. Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide. Arch Oral Biol 101:108-121 (2019). PubMed: 30927660
- Tabansky I et al. Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal. Proc Natl Acad Sci U S A 115:E6900-E6909 (2018). PubMed: 29967172
- Belvedere R et al. The Pharmaceutical Device Prisma®Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing. Int J Mol Sci 18:N/A (2017). PubMed: 28757565
- Barbaro NR et al. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep 21:1009-1020 (2017). PubMed: 29069584
- Marangoni A et al. Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study. BMC Res Notes 7:230 (2014). PubMed: 24721461
- Foster JD et al. Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol 111:659-74 (2014). PubMed: 24259545