MTEP hydrochloride，mGlu5拮抗剂(ab120035)
Key features and details
- Potent, selective mGlu5 antagonist
- CAS Number: 1186195-60-7
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
MTEP hydrochloride，mGlu5拮抗剂 -
描述
Potent，selective mGlu5拮抗剂 -
生物学描述
Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
1186195-60-7 -
化学结构
性能
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化学名称
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride -
分子量
236.72 -
分子式
C11H8N2S.HCl -
PubChem识别号
45073467 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc2nc(C#Cc1cccnc1)cs2.Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - MTEP hydrochloride, mGlu5 antagonist (ab120035)2D chemical structure image of ab120035, MTEP hydrochloride, mGlu5 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (25)
ab120035 被引用在 25 文献中.
- Hu Z et al. Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease. Transl Psychiatry 12:96 (2022). PubMed: 35260557
- Hu C et al. Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents. Front Cell Dev Biol 10:844378 (2022). PubMed: 35646890
- Zhang Y et al. Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats. J Alzheimers Dis 89:335-350 (2022). PubMed: 35871344
- Cannady R et al. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369 (2017). PubMed: 28320841
- Travaglia A et al. Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33 (2016). PubMed: 27428652