MRS 2179，P2Y1拮抗剂(ab120414)
Key features and details
- Potent, selective P2Y1 antagonist
- CAS Number: 101204-49-3
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
MRS 2179，P2Y1拮抗剂 -
描述
Potent，selective P2Y1拮抗剂 -
生物学描述
Potent, selective, competitive P2Y1 antagonist (Ki = 100 nM). Inhibits ATP induced glutamate release in vitro and inhibits ADP ability to evoke platelet shape change and aggregation.
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CAS编号
101204-49-3 -
化学结构
性能
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化学名称
2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate ammonium salt -
分子式
C11H17N5O9P2.xNH3 -
PubChem识别号
71308613 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N.N.N.O=P(O)(O)OCC1OC(C[C@@H]1OP(=O)(O)O)n3cnc2c(NC)ncnc23 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - MRS 2179, P2Y1 antagonist (ab120414)2D chemical structure image of ab120414, MRS 2179, P2Y1 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120414 被引用在 4 文献中.
- Wu J et al. P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol 23:6339-6349 (2017). PubMed: 28974901
- Zeng J et al. P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia. Neurochem Res 39:2240-50 (2014). PubMed: 25186167
- Campwala H et al. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127:4964-73 (2014). PubMed: 25271060
- Nandanan E et al. Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J Med Chem 42:1625-38 (1999). PubMed: 10229631