Monensin sodium salt，Na+ ionophore (ab120499)
Key features and details
- Na+ ionophore
- CAS Number: 22373-78-0
- Soluble in ethanol to 100 mM
- Form / State: Solid
- Source: Streptomyces cinnamonensis
概述
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产品名称
Monensin sodium salt，Na+ ionophore -
描述
Na+ ionophore -
生物学描述
Na+ ionophore. Forms lipophilic complexes with monovalent cations to induce Na+ influx and H+/K+ efflux. Increases intracellular Ca2+ levels. Exhibits diverse biological actions; displays antibacterial properties and modulates ion gradients and intracellular pH. Apoptosis inducer.
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CAS编号
22373-78-0 -
化学结构
性能
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化学名称
4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]- 3-methyloxolan-2-yl]oxolan-2-yl]- 9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid sodium salt -
分子量
692.86 -
分子式
C36H61NaO11 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC[C@]1(O)O[C@@H]([C@@H](C)C[C@H]1C)[C@H]2C[C@H](C)[C@@H](O2)[C@]3(CC)CC[C@@H](O3)[C@]5(C)CC[C@]4(C[C@H](O)C[C@](C)(O4)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O5 -
来源
Streptomyces cinnamonensis
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研究领域
图片
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Chemical Structure - Monensin sodium salt, Na+ ionophore (ab120499)2D chemical structure image of ab120499, Monensin sodium salt, Na+ ionophore
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (8)
ab120499 被引用在 8 文献中.
- Lu L et al. Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway. Adv Sci (Weinh) 10:e2206212 (2023). PubMed: 36698296
- Serter Kocoglu S et al. Effects of Monensin and Rapamycin Combination Therapy on Tumor Growth and Apoptosis in a Xenograft Mouse Model of Neuroblastoma. Antibiotics (Basel) 12:N/A (2023). PubMed: 37370314
- Watson J et al. Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival. Nat Commun 13:6589 (2022). PubMed: 36329028
- Zhou J et al. PLK1 Inhibition Induces Immunogenic Cell Death and Enhances Immunity against NSCLC. Int J Med Sci 18:3516-3525 (2021). PubMed: 34522178
- Qi L et al. Interleukin-33 activates and recruits natural killer cells to inhibit pulmonary metastatic cancer development. Int J Cancer 146:1421-1434 (2020). PubMed: 31709531
- Dai X et al. USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer. Theranostics 10:9332-9347 (2020). PubMed: 32802195
- Zhang Y et al. Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes. Immunol Lett 216:36-42 (2019). PubMed: 31568811
- Zhou M et al. Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-?B signal pathway. Oncoimmunology 5:e1180485 (2016). PubMed: 27622036