MMPIP，mGlu7 allosteric拮抗剂(ab120245)
Key features and details
- mGlu7 allosteric antagonist
- CAS Number: 479077-02-6
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
MMPIP，mGlu7 allosteric拮抗剂 -
描述
mGlu7 allosteric拮抗剂 -
生物学描述
Potent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120322)
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CAS编号
479077-02-6 -
化学结构
性能
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化学名称
6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)isoxazolo[4,5-c]pyridin-4(5H)-one -
分子量
333.35 -
分子式
C19H15N3O3 -
PubChem识别号
9945530 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 10 mM -
处理
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc(cc1)C3=Cc2onc(c2C(=O)N3C)c4ccncc4 -
来源
Synthetic
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研究领域
相关产品
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Related Products
图片
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Chemical Structure - MMPIP, mGlu7 allosteric antagonist (ab120245)2D chemical structure image of ab120245, MMPIP, mGlu7 allosteric antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120245 被引用在 3 文献中.
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733
- Klakotskaia D et al. Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning. Behav Brain Res 253:9-16 (2013). PubMed: 23827202
- Bahi A et al. Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats. Addict Biol 17:235-47 (2012). PubMed: 21392179