ML297 (VU0456810)，GIRK活化剂(ab143564)
Key features and details
- Potent, selective GIRK activator
- CAS Number:
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with warming)
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
ML297 (VU0456810)，GIRK活化剂 -
描述
Potent，selective GIRK活化剂 -
生物学描述
Potent, selective GIRK activator (EC50 = 160 nM). Shows anticonvulsant effects in vivo.
-
纯度
> 99% -
化学结构
性能
-
化学名称
1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea -
分子量
328.32 -
分子式
C17H14F2N4O -
PubChem识别号
56642816 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with warming) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Fc1ccc(cc1F)NC(=O)Nc3cc(C)nn3c2ccccc2 -
来源
Synthetic
-
研究领域
图片
-
Chemical Structure - ML297 (VU0456810), GIRK activator (ab143564)2D chemical structure image of ab143564, ML297 (VU0456810), GIRK activator
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab143564 被引用在 3 文献中.
- Sánchez-Rodríguez I et al. Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity. J Neurochem 153:362-376 (2020). PubMed: 31875959
- Nimitvilai S et al. Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. Neuropharmacology 137:1-12 (2018). PubMed: 29689260
- Huang Y et al. GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297. Biomed Pharmacother 101:362-370 (2018). PubMed: 29499411
