Minocycline hydrochloride，Antibiotic (ab120661)
Key features and details
- Antibiotic. Demonstrates multiple effects.
- CAS Number: 13614-98-7
- Purity: > 98%
- Soluble in DMSO to 100 mM (with warming) and in water to 25 mM (with warming)
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Minocycline hydrochloride，Antibiotic -
描述
Antibiotic. Demonstrates multiple effects. -
生物学描述
Antibiotic. Demonstrates anti-inflammatory, antiapoptotic, antioxidant and neuroprotective effects. Blood-brain barrier permeable. Matrix metalloproteinase (MMP) inhibitor (IC50 = 290 μM at stromelysin (MMP-3).
-
纯度
> 98% -
CAS编号
13614-98-7 -
化学结构
性能
-
化学名称
[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride -
分子量
493.94 -
分子式
C23H27N3O7.HCl -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM (with warming) and in water to 25 mM (with warming) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
来源
Synthetic
-
研究领域
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
图片
-
Chemical Structure - Minocycline hydrochloride, Antibiotic (ab120661)2D chemical structure image of ab120661, Minocycline hydrochloride, Antibiotic
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120661 被引用在 3 文献中.
- Long J et al. Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures. Brain Sci 13:N/A (2023). PubMed: 37239211
- Otsu Y et al. Functional Principles of Posterior Septal Inputs to the Medial Habenula. Cell Rep 22:693-705 (2018). PubMed: 29346767
- Li TF et al. Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing. Front Pharmacol 7:367 (2016). PubMed: 27761113