Methyllycaconitine citrate (MLA)，alpha7 Nicotinic receptor拮抗剂(ab120072)
Key features and details
- α7 Nicotinic receptor antagonist
- CAS Number: 112825-05-5
- Purity: > 97%
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Delphinium
概述
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产品名称
Methyllycaconitine citrate (MLA)，alpha7 Nicotinic receptor拮抗剂 -
描述
α7 Nicotinic receptor拮抗剂 -
别名
- MLA
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生物学描述
Potent, selective antagonist at α7-containing nicotinic receptors.
Also available in simple stock solutions (ab146684) - add 1 ml of water to get an exact, ready-to-use concentration. -
纯度
> 97% -
CAS编号
112825-05-5 -
化学结构
性能
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化学名称
[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate
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分子量
874.92 -
分子式
C37H50N2O10.C6H8O7 -
PubChem识别号
90479749 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]1[C@@]([C@H](C23)OC)([C@]5(C[C@@H]([C@H]6C[C@@H]4[C@@H]5[C@H]6OC)OC)O)O)OC)COC(=O)C7=CC=CC=C7N8C(=O)C[C@@H](C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O -
来源
Delphinium
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研究领域
图片
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Chemical Structure - Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist (ab120072)2D chemical structure image of ab120072, Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (8)
ab120072 被引用在 8 文献中.
- Wang TY et al. Effect of spirocyclopiperazinium salt compound LXM-15 on spinal nerve injury in rats. Eur J Pain 28:297-309 (2024). PubMed: 37668323
- Chang KW et al. PNU282987 alleviates Aß-induced anxiety and depressive-like behaviors through upregulation of a7nAChR by ERK-serotonin receptors pathway. Neurosci Lett 731:135118 (2020). PubMed: 32502508
- Nikiforuk A et al. The combination of memantine and galantamine improves cognition in rats: The synergistic role of the a7 nicotinic acetylcholine and NMDA receptors. Behav Brain Res 313:214-8 (2016). PubMed: 27435422
- Zhang Y et al. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via a7 receptor in hippocampus. Cell Res 26:728-42 (2016). PubMed: 27103432
- Sadigh-Eteghad S et al. Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function. Acta Cir Bras 30:736-42 (2015). PubMed: 26647792
- Baxter JC et al. Functional expression of a7-nicotinic acetylcholine receptors by muscle afferent neurons. J Neurophysiol 112:1549-58 (2014). PubMed: 24966300
- Uteshev VV Somatic integration of single ion channel responses of a7 nicotinic acetylcholine receptors enhanced by PNU-120596. PLoS One 7:e32951 (2012). PubMed: 22479351
- Bell KA et al. Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain a4 and ß2 subunits. Neuropharmacology 61:1379-88 (2011). PubMed: 21878344
