LY 367385，mGlu1a拮抗剂(ab120067)
Key features and details
- mGlu1a antagonist
- CAS Number: 198419-91-9
- Soluble in 1.1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
LY 367385，mGlu1a拮抗剂 -
描述
mGlu1a拮抗剂 -
生物学描述
Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant in vivo.
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CAS编号
198419-91-9 -
化学结构
性能
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化学名称
(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid -
分子量
209.20 -
分子式
C10H11NO4 -
PubChem识别号
5311261 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in 1.1 eq. NaOH to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc1cc(ccc1[C@H](N)C(=O)O)C(=O)O -
来源
Synthetic
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研究领域
图片
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Chemical Structure - LY 367385, mGlu1a antagonist (ab120067)2D chemical structure image of ab120067, LY 367385, mGlu1a antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (12)
ab120067 被引用在 12 文献中.
- Wong NF & Xu-Friedman MA Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses. J Neurosci 42:6211-6220 (2022). PubMed: 35790402
- Robin LM et al. Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory. Neuron 98:935-944.e5 (2018). PubMed: 29779943
- Colavita M et al. Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. Sci Rep 6:28454 (2016). PubMed: 27345695
- Eng AG et al. Transduction of group I mGluR-mediated synaptic plasticity by ß-arrestin2 signalling. Nat Commun 7:13571 (2016). PubMed: 27886171
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733