LY 341495，Group II拮抗剂(ab120199)
Key features and details
- Potent, selective group II antagonist. Group III antagonist at higher concentrations.
- CAS Number: 201943-63-7
- Soluble in DMSO to 10 mM and in 1.2 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
LY 341495，Group II拮抗剂 -
描述
Potent，selective group II拮抗剂. Group III拮抗剂at higher concentrations. -
生物学描述
Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo.
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CAS编号
201943-63-7 -
化学结构
性能
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化学名称
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid -
分子量
353.37 -
分子式
C20H19NO5 -
PubChem识别号
9819927 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 10 mM and in 1.2 eq. NaOH to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)[C@H]1C[C@@H]1[C@@](N)(CC2c4ccccc4Oc3ccccc23)C(=O)O -
来源
Synthetic
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研究领域
图片
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Chemical Structure - LY 341495, Group II antagonist (ab120199)2D chemical structure image of ab120199, LY 341495, Group II antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (11)
ab120199 被引用在 11 文献中.
- Mendis GDC et al. Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow. Sci Rep 9:121 (2019). PubMed: 30644434
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733
- Klar R et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci 35:7600-15 (2015). PubMed: 25972184
- Schauer C et al. Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol 114:1008-21 (2015). PubMed: 26063780
- Yamada K et al. Neuronal activity regulates extracellular tau in vivo. J Exp Med 211:387-93 (2014). PubMed: 24534188