LDN-57444, UCH-L1 inhibitor

关键信息

CAS 号

668467-91-2

纯度

>98%

形式

Solid

form

分子量

397.6 Da

分子式

C₁₇H₁₁Cl₃N₂O₃

PubChem

16760696

属性

Synthetic

溶解度

Soluble in DMSO to 50 mM

生化试剂名称

(Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

生物学描述

Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (K_i = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

经典 SMILES

CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

同分异构的 SMILES

CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

InChi

InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

InChiKey

OPQRFPHLZZPCCH-PGMHBOJBSA-N

IUPAC 名

[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate