AB144291

Latrunculin B, actin polymerization inhibitor

Name: Latrunculin B, actin polymerization抑制剂 (ab144291)| Abcam中文官网
Brand: Abcam Limited
SKU: AB144291
Price: 1906 CNY
Availability: InStock

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(45 Publications)

MW 395.5 Da, Purity >96%. Cell-permeable actin polymerization inhibitor. Forms a 1:1 complex with monomeric G-actin. Shows less potent growth inhibition effects on cancer cell lines than Latrunculin A, (ab144290) (IC₅₀ values are 7.1 and 4.8 μM for HCT116 and MDA-MB-435 cells respectively). Shows antiglaucoma effects in vivo. .

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Chemical Structure - Latrunculin B, actin polymerization inhibitor (AB144291)

Chemical Structure

Lab

Chemical Structure - Latrunculin B, actin polymerization inhibitor (AB144291)

2D chemical structure image of ab144291, Latrunculin B, actin polymerization inhibitor

关键信息

CAS 号

76343-94-7

纯度

>96%

形式

Solid

form

来源

Latrunculia magnifica

分子量

395.5 Da

分子式

C20H29NO5S

PubChem

6436219

属性

Native

溶解度

Soluble in DMSO (25 mg/ml)

Soluble in ethanol (25 mg/ml)

生化试剂名称

latrunculin B

生物学描述

Cell-permeable actin polymerization inhibitor. Forms a 1:1 complex with monomeric G-actin. Shows less potent growth inhibition effects on cancer cell lines than Latrunculin A, (ab144290) (IC₅₀ values are 7.1 and 4.8 μM for HCT116 and MDA-MB-435 cells respectively). Shows antiglaucoma effects in vivo.

经典 SMILES

CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=C1)C

同分异构的 SMILES

C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C1)/C

InChi

InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

InChiKey

NSHPHXHGRHSMIK-JRIKCGFMSA-N

IUPAC 名

(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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文献 (45)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:3988 PubMed40295523

2025

An RNA helicase coordinates with iron signal regulators to alleviate chilling stress in Arabidopsis.

Applications

Unspecified application

Species

Unspecified reactive species

Yingying Xing,Yawen Li,Xinmeng Gui,Xianyu Zhang,Qian Hu,Qiqi Zhao,Yongli Qiao,Ning Xu,Jun Liu

Frontiers in cellular and infection microbiology 15:1494200 PubMed39981379

2025

Inhibition of early EHDV2-Ibaraki infection steps in bovine cells by endosome alkalinization or ikarugamycin, but not by blockage of individual endocytic pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Maya Malka,Inbar Czaczkes,Shlomi Kashkash,Shirel Shachar,Eran Bacharach,Marcelo Ehrlich

Heliyon 10:e38214 PubMed39386786

2024

An open-source combined atomic force microscope and optical microscope for mechanobiology studies.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Delgado,Sarah Desroches,Gia Kang,Yousef Aldabii,Andrew R Harris

The EMBO journal 43:4274-4297 PubMed39143238

2024

Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly.

Applications

Unspecified application

Species

Unspecified reactive species

Eleonora Margheritis,Shirin Kappelhoff,John Danial,Nadine Gehle,Wladislaw Kohl,Rainer Kurre,Ayelén González Montoro,Katia Cosentino

Science advances 10:eadk1174 PubMed38968355

2024

Neural progenitor-derived Apelin controls tip cell behavior and vascular patterning.

Applications

Unspecified application

Species

Unspecified reactive species

Julian Malchow,Jean Eberlein,Wei Li,Benjamin M Hogan,Kazuhide S Okuda,Christian S M Helker

eLife 12: PubMed38829367

2024

Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Satyajit Mahapatra,Tomoyuki Takahashi

Current biology : CB 34:2132-2146.e5 PubMed38688282

2024

Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan A Jackson,Marlis Denk-Lobnig,Katherine A Kitzinger,Adam C Martin

iScience 27:109687 PubMed38680662

2024

Tumor invasiveness is regulated by the concerted function of APC, formins, and Arp2/3 complex.

Applications

Unspecified application

Species

Unspecified reactive species

Lautaro Baro,Rabeah A Almhassneh,Asifa Islam,M Angeles Juanes

Cell reports 43:113866 PubMed38416638

2024

Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation.

Applications

Unspecified application

Species

Unspecified reactive species

Harry Warner,Giulia Franciosa,Guus van der Borg,Britt Coenen,Felix Faas,Claire Koenig,Rinse de Boer,René Classens,Sjors Maassen,Maksim V Baranov,Shweta Mahajan,Deepti Dabral,Frans Bianchi,Niek van Hilten,Herre Jelger Risselada,Wouter H Roos,Jesper Velgaard Olsen,Laia Querol Cano,Geert van den Bogaart

Current biology : CB 34:615-622.e4 PubMed38199065

2024

PCP and Septins govern the polarized organization of the actin cytoskeleton during convergent extension.

Applications

Unspecified application

Species

Unspecified reactive species

Caitlin C Devitt,Shinuo Weng,Vidal D Bejar-Padilla,José Alvarado,John B Wallingford

View all publications

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Latrunculin B, actin polymerization inhibitor