Latrunculin A (LAT-A),Actin polymerization抑制剂(ab144290)
Key features and details
- Actin polymerization inhibitor. Potent antiproliferative agent.
- CAS Number: 76343-93-6
- Purity: > 95%
- Soluble in ethanol to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Cacospongia mycofijiensis
概述
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产品名称
Latrunculin A (LAT-A),Actin polymerization抑制剂 -
描述
Actin polymerization抑制剂. Potent antiproliferative agent. -
生物学描述
Actin polymerization inhibitor. Potent antiproliferative agent. Stabilizes monomeric G-actin. Shows greater potency than Latrunculin B (ab144291). Binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry. Inhibits growth of cancer cell lines (IC50 values are 142, 142, 142, 166 and 95 nM for A549, H522-T1, HT-29, U-937 and MDA-MB-43 cells respectively). Shows convulsant effects in vivo.
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纯度
> 95% -
CAS编号
76343-93-6 -
化学结构
性能
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化学名称
(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone -
分子量
421.55 -
分子式
C22H31NO5S -
PubChem识别号
445420 -
存放说明
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解度概述
Soluble in ethanol to 10 mM and in DMSO to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C -
来源
Cacospongia mycofijiensis
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (22)
ab144290 被引用在 22 文献中.
- Davaa G et al. Delivery of Induced Neural Stem Cells Through Mechano-Tuned Silk-Collagen Hydrogels for the Recovery of Contused Spinal Cord in Rats. Adv Healthc Mater 12:e2201720 (2023). PubMed: 36447307
- Phillips C et al. The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models. Cancer Res Commun 2:914-928 (2022). PubMed: 36922934
- de Los Ángeles Juricic Urzúa M et al. The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures. Traffic 23:174-187 (2022). PubMed: 35075729
- Shi L et al. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. J Cell Biol 221:N/A (2022). PubMed: 35575797
- Pineau J et al. Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes. Elife 11:N/A (2022). PubMed: 36111670