L779450，Raf kinase抑制剂(ab120837)
Key features and details
- Potent Raf kinase inhibitor
- CAS Number: 303727-31-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
L779450，Raf kinase抑制剂 -
描述
Potent Raf kinase抑制剂 -
生物学描述
Potent Raf kinase inhibitor (IC50 = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.
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纯度
> 98% -
CAS编号
303727-31-3 -
化学结构
性能
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化学名称
2-Chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol -
分子量
347.80 -
分子式
C20H14ClN3O -
PubChem识别号
9950176 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(cc1O)c2nc(nc2c3ccncc3)c4ccccc4 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - L779450, Raf kinase inhibitor (ab120837)2D chemical structure image of ab120837, L779450, Raf kinase inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120837 被引用在 3 文献中.
- Keshmiri Neghab H et al. Optogenetic Stimulation of Primary Cardiomyocytes Expressing ChR2. J Lasers Med Sci 12:e32 (2021). PubMed: 34733755
- Keshmiri Neghab H et al. Modulation of cardiac optogenetics by vitamin A. Biofactors 45:983-990 (2019). PubMed: 31509323
- Fritsche-Guenther R et al. Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis. Oncotarget 7:7960-9 (2016). PubMed: 26799289