L-cis-Diltiazem，cyclic nucleotide-gated channel blocker (ab120532)
Key features and details
- Selective cyclic nucleotide-gated channel blocker
- CAS Number: 42399-54-2
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
L-cis-Diltiazem，cyclic nucleotide-gated channel blocker -
描述
Selective cyclic nucleotide-gated channel blocker -
生物学描述
Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
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CAS编号
42399-54-2 -
化学结构
性能
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化学名称
(2R,3R)-(-)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride -
分子量
450.98 -
分子式
C22H26N2O4S.HCl -
PubChem识别号
198106 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O[C@H]1[C@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - L-cis-Diltiazem, cyclic nucleotide-gated channel blocker (ab120532)2D chemical structure image of ab120532, L-cis-Diltiazem, cyclic nucleotide-gated channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (5)
ab120532 被引用在 5 文献中.
- Das S et al. Redefining the role of Ca2+-permeable channels in photoreceptor degeneration using diltiazem. Cell Death Dis 13:47 (2022). PubMed: 35013127
- Camarena V et al. cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool. Elife 6:N/A (2017). PubMed: 29239726
- Weber L et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS One 12:e0172491 (2017). PubMed: 28273117
- Kalbe B et al. Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells. Front Physiol 7:339 (2016). PubMed: 27540365
- López F et al. Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5. J Neurosci 34:3268-78 (2014). PubMed: 24573286