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L-AP4，group III mGlu激动剂(ab120002)

Submit a review Q&A (1)References (22)
Chemical Structure - L-AP4, group III mGlu agonist (ab120002)

    Key features and details

    • Selective group III mGlu agonist
    • CAS Number: 23052-81-5
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      L-AP4，group III mGlu激动剂

    • 描述

      Selective group III mGlu激动剂

    • 生物学描述

      Selective group III mGlu receptor agonist.

      Also available in simple stock solutions (ab144481) - add 1 ml of water to get an exact, ready-to-use concentration.

    • CAS编号

      23052-81-5

    • 化学结构

      Chemical Structure

    性能

    图片

    • Chemical Structure - L-AP4, group III mGlu agonist (ab120002)
      Chemical Structure - L-AP4, group III mGlu agonist (ab120002)
      2D chemical structure image of ab120002, L-AP4, group III mGlu agonist

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (22)

    发表研究结果有使用 ab120002？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120002 被引用在 22 文献中.

    • Katada Y  et al. Starburst amacrine cells amplify optogenetic visual restoration through gap junctions. Mol Ther Methods Clin Dev 30:1-13 (2023). PubMed: 37324975
    • Špirková A  et al. Glutamate can act as a signaling molecule in mouse preimplantation embryos†. Biol Reprod 107:916-927 (2022). PubMed: 35746896
    • Ribeiro J  et al. Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors. Cell Rep 35:109022 (2021). PubMed: 33882303
    • Pérez-Fernández V  et al. Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina. Curr Biol 29:763-774.e5 (2019). PubMed: 30799247
    • Tikidji-Hamburyan A  et al. Rods progressively escape saturation to drive visual responses in daylight conditions. Nat Commun 8:1813 (2017). PubMed: 29180667
    View all Publications for this product

    客户评价及客户问答

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    Question

    1) Can I use PBS to dissolve both substances?
    2) How much volume of 1M NaOH should I use to neutralize the solution?
    3) Can I prepare a cocktail of both reagents ?

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    Answer

    Thank you for your enquiry regarding L-AP4 and cis-PDA. The lab send me the following information:

    As we do not currently undertake any of our own research we can only offer advice based on published literature. Both L-AP4 and cis-PDA have been previously dissolved in PBS for use in both rats and rabbits, respectively. It is therefore reasonable to believe that you will be able to use both compounds with PBS in your research. I have attached two papers for your reference.
    I can also provide the following information in reference to neutralizing solutions using 1M NaOH.

    L-AP4
    5.46 μl (1 mg)
    54.6 μl (10 mg)
    273.07 μl (50 mg)

    cis-PDA
    288.73 μl (50 mg)
    1.44 ml (250 mg)


    These values can be calculated using the following formula:
    { Mass of compound (mg) x 1000 } / { MW of compound x [NaOH] } = Vol (ml) NaOH
    In reference to your third point, unfortunately we have not come across previous literature describing a combination of the two compounds used as a cocktail. Since we do not test these combinations in-house I cannot guarantee any in vivo responses, however it is likely that at reasonable physiological concentrations you should see no adverse effects. Please note that you will need to add enough NaOH to neutralize both compounds.
    Please do not hesitate to contact us again if you require further assistance.

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