AB120002

L-AP4, group III mGlu agonist

Name: L-AP4, group III mGlu激动剂 (ab120002)| Abcam中文官网
Brand: Abcam Limited
SKU: AB120002
Price: 864 CNY
Availability: InStock

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(22 Publications)

MW 183.1 Da, Purity >99%. Selective group III mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.

查看别名

FLJ41058, G protein coupled receptor family C group 1 member F, GLUR, GLUR8, GPRC1C, GPRC1D, GPRC1F, GPRC1H, GRM3_HUMAN, GRM4_HUMAN, GRM8_HUMAN, GluR-3, Glutamate metabotropic receptor 3, Glutamate receptor metabotropic 3, Glutamate receptor metabotropic 4, Glutamate receptor metabotropic 6, Glutamate receptor metabotropic 8, MGC126724, MGLUR3, MGLUR6, MGlu3, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 6 precursor, Metabotropic glutamate receptor 8, Smp_128940, mGlu4, mGlu6, mGlu8, mGluR4

1 Images

Chemical Structure - L-AP4, group III mGlu agonist (AB120002)

Chemical Structure

Lab

Chemical Structure - L-AP4, group III mGlu agonist (AB120002)

2D chemical structure image of ab120002, L-AP4, group III mGlu agonist

关键信息

CAS 号

23052-81-5

纯度

>99%

形式

Solid

form

分子量

183.1 Da

分子式

C4H10NO5P

PubChem

179394

属性

Synthetic

生化试剂名称

(2S)-2-amino-4-phosphonobutanoic acid

生物学描述

Selective group III mGlu agonist.

经典 SMILES

C(CP(=O)(O)O)C(C(=O)O)N

同分异构的 SMILES

C(CP(=O)(O)O)[C@@H](C(=O)O)N

InChi

InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1

InChiKey

DDOQBQRIEWHWBT-VKHMYHEASA-N

IUPAC 名

(2S)-2-amino-4-phosphonobutanoic acid

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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文献 (22)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Methods & clinical development 30:1-13 PubMed37324975

2023

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.

Applications

Unspecified application

Species

Unspecified reactive species

Yusaku Katada,Hiromitsu Kunimi,Naho Serizawa,Deokho Lee,Kenta Kobayashi,Kazuno Negishi,Hideyuki Okano,Kenji F Tanaka,Kazuo Tsubota,Toshihide Kurihara

Biology of reproduction 107:916-927 PubMed35746896

2022

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Špirková,Veronika Kovaříková,Zuzana Šefčíková,Jozef Pisko,Martina Kšiňanová,Juraj Koppel,Dušan Fabian,Štefan Čikoš

Cell reports 35:109022 PubMed33882303

2021

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors.

Applications

Unspecified application

Species

Unspecified reactive species

Joana Ribeiro,Christopher A Procyk,Emma L West,Michelle O'Hara-Wright,Monica F Martins,Majid Moshtagh Khorasani,Aura Hare,Mark Basche,Milan Fernando,Debbie Goh,Neeraj Jumbo,Matteo Rizzi,Kate Powell,Menahil Tariq,Michel Michaelides,James W B Bainbridge,Alexander J Smith,Rachael A Pearson,Anai Gonzalez-Cordero,Robin R Ali

Current biology : CB 29:763-774.e5 PubMed30799247

2019

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

Applications

Unspecified application

Species

Unspecified reactive species

Víctor Pérez-Fernández,Nina Milosavljevic,Annette E Allen,Kirstan A Vessey,Andrew I Jobling,Erica L Fletcher,Paul P Breen,John W Morley,Morven A Cameron

Nature communications 8:1813 PubMed29180667

2017

Rods progressively escape saturation to drive visual responses in daylight conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Tikidji-Hamburyan,Katja Reinhard,Riccardo Storchi,Johannes Dietter,Hartwig Seitter,Katherine E Davis,Saad Idrees,Marion Mutter,Lauren Walmsley,Robert A Bedford,Marius Ueffing,Petri Ala-Laurila,Timothy M Brown,Robert J Lucas,Thomas A Münch

Nature chemical biology 10:813-5 PubMed25173999

2014

An allosteric modulator to control endogenous G protein-coupled receptors with light.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Pittolo,Xavier Gómez-Santacana,Kay Eckelt,Xavier Rovira,James Dalton,Cyril Goudet,Jean-Philippe Pin,Artur Llobet,Jesús Giraldo,Amadeu Llebaria,Pau Gorostiza

PloS one 9:e106148 PubMed25165854

2014

Step-by-step instructions for retina recordings with perforated multi electrode arrays.

Applications

Unspecified application

Species

Unspecified reactive species

Katja Reinhard,Alexandra Tikidji-Hamburyan,Hartwig Seitter,Saad Idrees,Marion Mutter,Boris Benkner,Thomas A Münch

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:79-94 PubMed24381270

2014

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.

Applications

Unspecified application

Species

Unspecified reactive species

Shen Yin,Meredith J Noetzel,Kari A Johnson,Rocio Zamorano,Nidhi Jalan-Sakrikar,Karen J Gregory,P Jeffrey Conn,Colleen M Niswender

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:18951-65 PubMed24285900

2013

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Bruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmann,Fanny Malhaire,Eric Chapuy,Youssef Aissouni,Monique Etienne,Emmanuel Bourinet,Francine Acher,Jean-Philippe Pin,Alain Eschalier,Cyril Goudet

The Journal of pharmacology and experimental therapeutics 344:624-36 PubMed23257312

2012

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization.

Applications

Unspecified application

Species

Unspecified reactive species

Mikhail Kalinichev,Mélanie Rouillier,Francoise Girard,Isabelle Royer-Urios,Bruno Bournique,Terry Finn,Delphine Charvin,Brice Campo,Emmanuel Le Poul,Vincent Mutel,Sonia Poli,Stuart A Neale,Thomas E Salt,Robert Lütjens

View all publications

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L-AP4, group III mGlu agonist