Kynurenic acid，endogenous ionotropic / nicotinic拮抗剂(ab120064)
Key features and details
- Endogenous ionotropic / nicotinic antagonist
- CAS Number: 492-27-3
- Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Kynurenic acid，endogenous ionotropic / nicotinic拮抗剂 -
描述
Endogenous ionotropic / nicotinic拮抗剂 -
生物学描述
Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)
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CAS编号
492-27-3 -
化学结构
性能
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化学名称
4-Hydroxyquinoline-2-carboxylic acid -
分子量
189.17 -
分子式
C10H7NO3 -
PubChem识别号
3845 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)c1cc(O)c2ccccc2n1 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)2D chemical structure image of ab120064, Kynurenic acid, endogenous ionotropic / nicotinic antagonist
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Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)Image from Rudolph S et al., Neuron. 2011;70(5):991-1004. Fig 3.; doi: 10.1016/j.neuron.2011.03.029 with permission from Elsevier.C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (28)
ab120064 被引用在 28 文献中.
- Chou MY et al. Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice. Commun Biol 6:267 (2023). PubMed: 36918719
- Barnes JL et al. Developmentally Transient CB1Rs on Cerebellar Afferents Suppress Afferent Input, Downstream Synaptic Excitation, and Signaling to Migrating Neurons. J Neurosci 40:6133-6145 (2020). PubMed: 32631938
- Heubl M et al. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun 8:1776 (2017). PubMed: 29176664
- Hiu T et al. Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain 139:468-80 (2016). PubMed: 26685158
- Zarnowska ED et al. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology 93:171-178 (2015). PubMed: 25680234