Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online

KW2449 (ab273596)

Submit a review Submit a question
Chemical Structure - KW2449 (ab273596)

    Key features and details

    • Inhibits FLT3, ABL, and Aurora kinases
    • CAS Number: 1000669-72-6
    • Purity: > 98%

    • Soluble in DMSO to 50 mM

    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      KW2449

    • 描述

      Inhibits FLT3，ABL，and Aurora kinases

    • 生物学描述

      Multi targeted inhibitor of FLT3 ( with an IC50 of 6.6nM), ABL, ABL-T315I, and Aurora kinase. Tumor growth inhibition in FLT3-mutated xenograft model in vitro. Shows a potent and significant antitumor effect in a dose-dependent manner in MOLM-13 tumour xenograft model in vivo.

    • 纯度

      > 98%

    • CAS编号

      1000669-72-6

    • 化学结构

      Chemical Structure

    性能

    • 化学名称

      [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

    • 分子量

      332.40

    • 分子式

      C20H20N4O

    • PubChem识别号

      11427553

    • 存放说明

      Shipped at room temperature. Store at -20°C.

    • 溶解度概述

      Soluble in DMSO to 50 mM

    • 处理

      Refer to SDS for further information

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43

    • 来源

      Synthetic

    图片

    • Chemical Structure - KW2449 (ab273596)
      Chemical Structure - KW2449 (ab273596)

      Chemical structure of KW2449, 1000669-72-6

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (0)

    发表研究结果有使用 ab273596？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab273596 尚未被引用在任何文献中。

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    There are currently no Customer reviews or Questions for ab273596.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com