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KB-R7943，NCX抑制剂(ab120284)

Reviews (1) Submit a question References (4)
Chemical Structure - KB-R7943, NCX inhibitor (ab120284)

    Key features and details

    • NCX inhibitor. TRPC blocker.
    • CAS Number: 182004-65-5
    • Soluble in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      KB-R7943，NCX抑制剂

    • 描述

      NCX抑制剂. TRPC blocker.

    • 生物学描述

      Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).

    • CAS编号

      182004-65-5

    • 化学结构

      Chemical Structure

    性能

    图片

    • Chemical Structure - KB-R7943, NCX inhibitor (ab120284)
      Chemical Structure - KB-R7943, NCX inhibitor (ab120284)
      2D chemical structure image of ab120284, KB-R7943, NCX inhibitor

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (4)

    发表研究结果有使用 ab120284？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120284 被引用在 4 文献中.

    • Wong RW  et al. An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing. PLoS Pathog 16:e1008307 (2020). PubMed: 32069328
    • Wong RW  et al. Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling. Sci Rep 8:850 (2018). PubMed: 29339801
    • Di Giuro CML  et al. Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells. Pflugers Arch 469:1287-1299 (2017). PubMed: 28497275
    • Sherkhane P & Kapfhammer JP Chronic pharmacological blockade of the Na(+) /Ca(2+) exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures. Eur J Neurosci N/A:N/A (2017). PubMed: 28715135

    客户评价及客户问答

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    Fairly unspecific, but potent inhibitor for the reverse mode of Na+/Ca2+ exchanger

     Excellent
    Abreviews
    abreview image
    KB-R7943 has been used to inhibit the reverse mode of Na+/Ca2+ exchanger (NCX) in mouse cerebellar slice cultures. The cerebellar slices of P8 mouse pups were treated with KB-R7943 (15 uM diluted in 1:1 DMSO/ETOH solution) for 7-9 days with 5% Co2 at 37 degree C . Further, these slices were fixed with cold 4% Paraformaldehyde and immunohistochemistry was performed on these slices using anti-Calbindin antibody (Swant).
    The blockade of the reverse mode of NCX by KB-R7943 severely reduced the dendritic arbour of Purkinje cells and induced thickened distal dendrites in mouse cerebellar slice cultures.

    Image description: Reduced dendritic arbour of mouse Purkinje cell with thickened distal dendrites.
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    DR. Pradeep Sherkhane

    Verified customer

    提交于 Aug 25 2017

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